On January 9, 2026, the European Commission published a draft proposal to introduce technical revisions to REACH Annex XVII. The proposal seeks to align the annex with new hazard classifications incorporated into the CLP Regulation in 2024 and 2025, with the key changes focusing on extending the list of restricted carcinogenic, mutagenic, and reprotoxic (CMR) substances.
Key Updates
Appendix 1 (Carcinogens: Category 1A)
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New Substance EC No CAS No Vinyl fluoride 200-832-6 75-02-5 |
Appendix 2 (Carcinogens: Category 1B)
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New Substance EC No CAS No Multi-walled carbon tubes (synthetic graphite in tubular shape) with a geometric tube diameter range ≥ 30 nm to < 3 μm and a length ≥ 5 μm and aspect ratio > 3:1, including multi-walled carbon nanotubes, MWC(N)T – – Acetone oxime 204-820-1 127-06-0 Benthiavalicarb-isopropyl (ISO); isopropyl [(S)-1-{[(R)-1-(6- fluoro-1,3-benzothiazol-2-yl)ethyl]carbamoyl}-2- methylpropyl]carbamate – 177406-68-7 1,4-Dichloro-2-nitrobenzene 201-923-3 89-61-2 Trimethyl phosphate 208-144-8 512-56-1 Barium chromate 233-660-5 10294-40-3 1,1-dichloroethylene; vinylidene chloride 200-864-0 75-35-4 |
Appendix 4 (Germ cell mutagens: Category 1B)
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New Substance EC No CAS No N,N′-Methylenediacrylamide 203-750-9 110-26-9 Trimethyl phosphate 208-144-8 512-56-1 |
Appendix 6 (Reproductive toxicants: Category 1B)
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New Substance EC No CAS No Trimethyl borate 204-468-9 121-43-7 Perboric acid, sodium salt [1] Perboric acid, sodium salt, monohydrate [2] Perboric acid (HBO(O₂)), sodium salt, monohydrate [3] Sodium peroxoborate [4] Sodium perborate [5] 234-390-0 [1] 234-390-0 [2] - [3] -[4] 239-172-9 [5] 11138-47-9 [1] 12040-72-1 [2] 10332-33-9 [3] - [4] 15120-21-5 [5] Perboric acid (H₃BO₂(O₂)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O₂)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] 239-172-9 [1] 234-390-0 [2] - [3] 13517-20-9 [1] 37244-98-7 [2] - [4] 10486-00-7 [3] - [4] Sodium peroxometaborate 231-556-4 7632-04-4 Reaction mass of 1,3-dioxan-5-ol and 1,3-dioxolan-4- ylmethanol – – 2-(Dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4- (morpholin-4-yl)phenyl]butan-1-one 438-340-0 119344-86-4 Sodium 3-(allyloxy)-2-hydroxypropanesulphonate 258-004-5 52556-42-0 Tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4 Dinitrogen oxide (N₂O) 233-032-0 10024-97-2 Trimethyl phosphate 208-144-8 512-56-1 2-Bromo-3,3,3-trifluoroprop-1-ene – 1514-82-5 2,3-Epoxypropyl isopropyl ether 223-672-9 4016-14-2 α,α'-Propylenedinitrilodi-o-cresol 202-374-2 94-91-7 2-Ethylhexanoic acid, monoester with propane-1,2-diol 285-503-5 85114-00-7 Tetrahydrofurfuryl methacrylate 219-529-5 2455-24-5 9-Octadecenoic acid (Z)-, sulfonated, potassium salts [1] Reaction products of fatty acids, C18 (unsaturated) alkyl with sulfur trioxide, potassium salts [2] 9(Or 10)-sulphooctadecanoic acid, potassium salt [3] 271-843-1 [1] - [2] 68609-93-8 [1] - [2] 267-966-5 [3] 67968-63-2 [3] |
The draft is presently subject to public consultation, with comments accepted until February 6, 2026. Following adoption, the regulation will take effect 20 days after its publication in the Official Journal of the European Union.
